Female BHRT Kit
Important Safety Information
Female BHRT Kit
Hormone TherapyBLACK BOX WARNING
WARNING: Cardiovascular Disorders, Breast Cancer, Endometrial Cancer, and Dementia
Estrogens increase the risk of endometrial cancer in women with a uterus when used without progestins. Adding a progestin (such as progesterone) is recommended to reduce this risk. Estrogens with or without progestins should not be used for the prevention of cardiovascular disease or dementia.
Risks Include:
- Increased risk of stroke and deep vein thrombosis (DVT)
- Increased risk of invasive breast cancer
- Increased risk of probable dementia in postmenopausal women aged 65 or older
Use the lowest effective dose for the shortest duration consistent with treatment goals and patient risks.
Common Side Effects
Estradiol Patch
- Skin irritation at the application site
- Breast tenderness
- Bloating
- Nausea
- Headache
- Mood changes
Estradiol Vaginal Cream
- Vaginal irritation or discharge
- Local itching or discomfort
- Spotting
Progesterone SR Capsules
- Grogginess or drowsiness
- Dizziness
- Breast tenderness
- Bloating
- Mood swings
- Spotting or breakthrough bleeding
More Serious Side Effects (less common)
- Blood clots (DVT, pulmonary embolism)
- Stroke or heart attack
- Gallbladder disease
- Breast lumps or unusual nipple discharge
- Vision changes
- Severe headache or chest pain
Seek immediate medical attention if you experience any of these symptoms.
Warnings (serious risks)
- Estrogen therapy without adequate progestin increases the risk of endometrial hyperplasia and cancer in women with a uterus.
- Both estrogen and progesterone therapy have been associated with an increased risk of stroke, blood clots, and breast cancer.
- Hormone therapy may affect lipid metabolism, liver enzymes, and thyroid function.
- Progesterone may cause drowsiness; avoid driving or operating heavy machinery until you know how it affects you.
Contraindications (not recommended for)
Do not use if you:
- Have a known or suspected history of breast cancer, endometrial cancer, or estrogen-dependent tumors
- Have active or recent blood clots or thromboembolic disorders
- Have liver dysfunction or disease
- Are currently pregnant or may become pregnant
- Have unexplained vaginal bleeding
- Are allergic to estradiol, progesterone, or any ingredients in the compounded formulation
Drug Interactions
- Certain seizure medications, antibiotics, and antifungals may alter hormone metabolism
- Thyroid hormone levels may be affected by estrogen therapy
- St. John’s Wort may reduce hormone effectiveness
Always inform your provider of all prescription, over-the-counter, and herbal products you are taking.
Pregnancy & Breastfeeding
Hormone therapy should not be used during pregnancy or while breastfeeding. If you become pregnant while using your hormone kit, discontinue use and contact your provider immediately.
Storage
- Estradiol Patch: Store at room temperature. Keep in original pouch until ready to apply.
- Estradiol Vaginal Cream: Store at room temperature. Avoid extreme heat or freezing.
- Progesterone SR Capsules: Store in a cool, dry place away from light and moisture.
Keep all medications out of reach of children.
Have Questions?
Patients should consult their healthcare provider if they have questions about their dosing, symptoms, risks, or treatment options. Never change or stop hormone therapy without provider supervision.